The dancer is a woman with purple hair and a nurse costume. She starts out wearing a pink nurse jacket over a purple dress, a pink nurse's headband, and wears pink stilettos. Her jacket has two white-on-purple medical crosses on it, and her headband has one. When it transitions to the chorus, her outfit and hair change from pink to pitch black, however, the crosses on her outfit remain visible. On Just Dance Wii, the dancer simply darkens instead. During the bridge, she flashes pink before remaining pitch black in the chorus. In the remake, the dancer has lighter and more realistic color scheme, and her outline is now pink instead of blue.
The routine takes place in what is supposed to be a nuclear central room, with a hazard sign and many lights. In the chorus, it turns into a red unrealistic room with horizontal neon lines.
The red room is completely different; it has a pixelated rose in the background and cherry red electricity circles coming out of it.
In the 20150325_1222 version of the Just Dance Now files, Toxic's files were no longer accessible. However, later in the 20150422_1529 version, Toxic was re-added to the files with a different icon and different pictograms.
Mehdi Kerkouche, a choreographer for the series, performed Toxic for his X Factor audition in 2011.