The dancer is a woman with purple hair and a nurse costume. She starts out wearing a pink nurse jacket over a purple dress, a pink nurse's headband, and wears pink stilettos. Her jacket has two white-on-purple medical crosses on it, and her headband has one. When it transitions to the chorus, her outfit and hair change from pink to pitch black, however, the crosses on her outfit remain visible. On Just Dance Wii, the dancer simply darkens instead. During the bridge, she flashes pink before remaining pitch black in the chorus. In the remake, the dancer has lighter and more realistic color scheme, and her outline is now pink instead of blue.
The routine takes place in what is supposed to be a nuclear central room, with a radiation sign, and many lights. In the chorus, it turns into a red unrealistic room with horizontal neon lines.
The red room is completely different; it has a pixelated rose in the background and cherry red electricity circles coming out of it.
In the 20150325_1222 version of the Just Dance Now files, Toxic's files were no longer accessible. However, later in the 20150422_1529 version, Toxic was re-added to the files with a different icon and different pictograms.
Mehdi Kerkouche, a choreographer for the series, performed Toxic for his X Factor audition in 2011.
On the menu icons in Just Dance 2 and Just Dance Wii, the coach is missing her glove, and in place of it is a bracelet which is supposed to be on her other arm.
In the Japanese version, the hazard sign is replaced with a caution sign and the placement of motions of the doors that open are rearranged, like in the Beta version of the European routine.
On the menu icons in Just Dance 2, Just Dance 3, Just Dance: Greatest Hits/Best Of, the big hazard sign has two little hazard signs inside of it, even though they are not present in-game. This is also the case with the warning sign in Just Dance Wii.